Biomolecular Engineering and Bioinformatics B.S.

Information and Policies

Introduction

The biomolecular engineering and bioinformatics major includes the biomolecular engineering (BME) and bioinformatics (BINF) concentrations. The BME concentration is designed for students interested in protein engineering, stem cell engineering, and synthetic biology. The emphasis is on designing biomolecules (DNA, RNA, proteins) and cells for particular functions, and the underlying sciences are biochemistry and cell biology.

The BINF concentration combines mathematics, science, and engineering to explore and understand biological data from high-throughput experiments, such as genome sequencing, gene-expression chips, and proteomics experiments. The program builds upon the research and academic strengths of the faculty in the Biomolecular Engineering Department.

In both concentrations, students participate in a capstone experience. Options for the senior capstone experience include

Senior Design—a three-quarter group project intended to prepare students for work in industry,
a three-quarter, including summer, full-time synthetic biology project based on the iGEM competition,
a three-quarter Senior thesis,
or an Advanced bioinformatics course series. The last option is the required capstone for students participating in the bioinformatics concentrations.

All capstone options involve working closely with faculty and other researchers at UCSC, analyzing ideas, developing technologies, and discovering new approaches. Application areas include biomolecular sensors and systems, nano-electronic implants, assistive technologies for the elderly and disabled, bioinformatics, microfluidics, nanoscale biotechnology, environmental monitoring, and other areas at the junction between engineering and the life sciences.

More information about bioengineering research and undergraduate research opportunities can be found at Undergraduate Research Opportunities, the Genomics Institute, the Program in Biomedical Sciences and Engineering, the STEM Maximizing Access to Research Careers (MARC) program, and the STEM diversity programs.

The program has course requirements in mathematics, science, and engineering. Students interested in Biomolecular Engineering and Bioinformatics as a major should contact the Baskin Engineering advising office (bsoeadvising@ucsc.edu) before enrolling in any courses at UCSC. Early advising is particularly important before choosing calculus and physics courses.

Biomolecular engineering and bioinformatics students may continue their research and studies at UCSC in any of several graduate programs. Information may be found at the Division of Graduate Studies website.

The immense growth of biological information stored in computerized databases has led to a critical need for people who can understand the languages, tools, and techniques of statistics, science, and engineering. A classically trained scientist may be unfamiliar with the statistical and algorithmic knowledge required in this field. A classically trained engineer may be unfamiliar with the chemistry and biology required in the field. Thus, this major strives for a balance of the two: an engineer focused on the problems of the underlying science or, conversely, a scientist focused on the use of engineering tools for analysis and discovery.

Program Learning Outcomes

A biomolecular engineering and bioinformatics student completing the program should:

have a broad knowledge of science and engineering disciplines including biology, chemistry, mathematics, statistics, and computer science; those completing the BINF concentration will also have a detailed knowledge of mathematics, statistics, and computer science; and, those completing the BME concentration will have broader knowledge in biology and chemistry;
be able to apply their knowledge to identify, formulate, and solve engineering design problems;
be able to write programs in Python;
be able to find and use information from a variety of sources, including books, journal articles, online encyclopedias, and manufacturer data sheets;
be able to design and conduct experiments, as well as to analyze and interpret data;
be able to work effectively with partners and on teams;
be able to communicate problems, experiments, and design solutions in writing, orally, and as posters; and
be able to apply ethical reasoning to make decisions about engineering methods and solutions in a global, economic, environmental, and societal context.

Academic Advising for the Program

The Baskin Engineering Undergraduate Advising office offers general advising for prospective and declared undergraduates majoring in Baskin Engineering programs. The office handles major declarations, transfer credits, course substitutions, articulations, and degree certifications. Undergraduate students obtain and submit all paperwork requiring departmental approval to the undergraduate advising office. Transfer students should also refer to the Transfer Information and Policy section.

Baskin Engineering Building, Room 225
bsoeadvising@ucsc.edu
(831) 459-5840

Getting Started in the Major: Frosh

This is a course-intensive and/or sequential program, and students who intend to pursue this major must begin taking classes for the major in their first year at the University of California, Santa Cruz. Timely completion of the degree will require completion of a general Chemistry series (CHEM 1, CHEM 3, or CHEM 4) and Engineering Calculus ( MATH19) during the first year. Math placement is required for one or more of the foundational courses for this major. For more information, please review the Math Placement website.

Transfer Information and Policy

Transfer Admission Screening Policy

Transfer students need to complete the equivalents of eight courses from the following list with a GPA in those courses of 2.8 or better:

BME 80G /PHIL 80G	Bioethics in the 21st Century: Science, Business, and Society	5
BIOL 20A	Cell and Molecular Biology	5
MATH 19A	Calculus for Science, Engineering, and Mathematics	5
MATH 19B	Calculus for Science, Engineering, and Mathematics	5
AM 10	Mathematical Methods for Engineers I	5
CHEM 8A	Organic Chemistry	5
CHEM 8B	Organic Chemistry	5
	Either these courses
CHEM 1A	General Chemistry	5
CHEM 1B	General Chemistry	5
CHEM 1C	General Chemistry	5
	or these courses
CHEM 3A	General Chemistry	5
CHEM 3B	General Chemistry	3
CHEM 3C	General Chemistry	3
	or these courses
CHEM 4A	Advanced General Chemistry: Molecular Structure and Reactivity	5
CHEM 4B	Advanced General Chemistry: Molecular Structure and Reactivity	5

Although not required for admission, transfer students are strongly recommended to complete at least ten courses from the above list if they wish to graduate in two years. Students with fewer than 10 transferable courses may find it difficult to complete the major in only two more years.

Prospective students are encouraged to prioritize required and recommended major preparation, and may additionally complete courses that articulate to UC Santa Cruz general education requirements as time allows.

Transferring to Biomolecular Engineering

Students transferring into the biomolecular engineering concentration may also count any of the following:

PHYS 5A	Introduction to Physics I	5
PHYS 5B	Introduction to Physics II	5
BME 21L	Introduction to Basic Laboratory Techniques	3
AM 20	Mathematical Methods for Engineers II	5

Transferring to Bioinformatics

Students transferring into the bioinformatics concentration may also count any of the following:

CSE 16	Applied Discrete Mathematics	5
CSE 13S	Computer Systems and C Programming	7
CSE 30	Programming Abstractions: Python	7

Transfer students may use courses articulated to PHIL 22, PHIL 24, or PHIL 28 in place of BME 80G, if these courses are taken prior to registering at UC Santa Cruz.

Getting Started in the Major: Transfer Students

Successful transition to UC Santa Cruz happens with early advisor contact, preparing and submitting course descriptions for articulation purposes, and taking summer session courses prior to their first fall quarter. Specific information for transfer students can be found at the Baskin Engineering Transfer webpage. Transfer students should declare their major during their first quarter at UCSC; instructions for declaring a major at Baskin Engineering are on the major declaration webpage.

Major Qualification Policy and Declaration Process

Major Qualification

In order to be admitted into the biomolecular engineering and bioinformatics major students must be listed as a proposed major within Baskin Engineering. Please refer to Baskin Engineering's "Prospective Students", "Admitted Students" and its "Current Students" sections in the catalog and the Undergraduate Affairs website for more information.

In addition to being listed as a proposed Baskin Engineering major, students must have completed at least 45 credits with a GPA of 2.8 or better in courses required for the major. Students with more than 7 credits of grades of NP, C-, D+, D, D-, or F in these courses are not qualified for the major.

Students wishing to declare the biomolecular engineering and bioinformatics major after the sixth quarter must appeal, must already have a declared major in which they have completed at least one major requirement course and be making reasonable progress, and must have completed 10 more credits of required courses in the biomolecular engineering and bioinformatics major for each additional quarter.

Transfer students should refer to the Transfer Information and Policy section.

Appeal Process

Students may appeal a major qualification decision by filing a petition with Baskin Engineering Advising. The appeal process is described at the Baskin Engineering Undergraduate Affairs website.

If you have further questions concerning the appeal process, please contact the Undergraduate Advising office at (831) 459-5840 or email bsoeadvising@ucsc.edu.

How to Declare a Major

Instructions for declaring a major in Baskin Engineering are on the division's website here.

Letter Grade Policy

Baskin Engineering requires letter grades for all courses in an engineering major.

Course Substitution Policy

Please refer to the Undergraduate Affairs Policies, Forms and Petitions website for Baskin Engineering policies about substitutions and taking courses at other institutions after enrolling at UC Santa Cruz.

Double Majors and Major/Minor Combinations Policy

Double majors with other biology-related majors are permitted for the bioinformatics concentration, but not for the biomolecular engineering concentration.

The BMEB major cannot be combined with a bioinformatics minor.

Study Abroad

Students are encouraged to investigate studying for short periods of time (a summer or a quarter) at other institutions, to broaden their education.

The BME Department has established an exchange program with Danish Technical University (DTU), which makes study there for one semester relatively easy, particularly for the bioinformatics concentration. Proposed plans of study should still be cleared with the undergraduate director.

Other exchange programs are also being developed.

Honors

Biomolecular engineering and bioinformatics majors are considered for "Honors in the Major" and "Highest Honors in the Major" based on their GPA and on results of undergraduate research. Students with a GPA of 3.7 or higher receive "Highest Honors in the Major." Students with a GPA of 3.3 or higher, but lower than 3.7, receive "Honors in the Major." Students with particularly significant accomplishments in undergraduate research may receive honors or highest honors with a lower GPA. Students who have been found guilty of academic misconduct are not eligible for either honors or highest honors.

Because of the enormous breadth of requirements, biomolecular engineering and bioinformatics majors are urged to take honors courses or sections to get as much as possible out of the courses they take in each field.

Biomolecular Engineering Concentration

The biomolecular engineering concentration focuses on wet-lab work, but with a modern appreciation for the statistics and computational tools needed for high-throughput experimentation.

Course Requirements

Biomolecular engineering concentration majors must complete the following courses:

Lower-Division Courses

Biology

BIOL 20A

Cell and Molecular Biology

Bioethics

BME 80G

/PHIL 80G

Bioethics in the 21st Century: Science, Business, and Society

Chemistry

Select one of the following General Chemistry series:

	Either these courses
CHEM 1A	General Chemistry	5
CHEM 1B	General Chemistry	5
CHEM 1M	General Chemistry Laboratory	2
CHEM 1C	General Chemistry	5
CHEM 1N	General Chemistry Laboratory	2
	or these courses
CHEM 3A	General Chemistry	5
CHEM 3B	General Chemistry	3
CHEM 3BL	General Chemistry Lab	2
CHEM 3C	General Chemistry	3
CHEM 3CL	General Chemistry Lab	2
	or these courses
CHEM 4A	Advanced General Chemistry: Molecular Structure and Reactivity	5
CHEM 4AL	Advanced General Chemistry Lab	2
CHEM 4B	Advanced General Chemistry: Molecular Structure and Reactivity	5
CHEM 4BL	Advanced General Chemistry Lab	2

Organic Chemistry

All of the following courses:

CHEM 8A	Organic Chemistry	5
CHEM 8B	Organic Chemistry	5

Laboratory Training

All of the following courses:

BME 21L	Introduction to Basic Laboratory Techniques	3
BME 22L	Foundations of Design and Experimentation in Molecular Biology, Part I	2
BME 23L	Foundations of Design and Experimentation in Molecular Biology, Part II	2

Mathematics

Choose one of the following options:

	Either these courses
MATH 19A	Calculus for Science, Engineering, and Mathematics	5
MATH 19B	Calculus for Science, Engineering, and Mathematics	5
	or these courses
MATH 20A	Honors Calculus	5
MATH 20B	Honors Calculus	5

MATH 19A and MATH 19B are the recommended sequence. Credit for one or both can be granted with adequate performance on the College Entrance Examination Board (CEEB) calculus AB or BC Advanced Placement examination.

Applied Math

Both of these applied math courses:

AM 10	Mathematical Methods for Engineers I	5
AM 20	Mathematical Methods for Engineers II	5

Students may substitute MATH 21 for AM 10, and MATH 24 for AM 20, if they can show MATLAB proficiency at the level of students in the AM class that they are replacing.

Physics

All of the following courses:

PHYS 5A	Introduction to Physics I	5
PHYS 5L	Introduction to Physics I Laboratory	1
PHYS 5B	Introduction to Physics II	5
PHYS 5M	Introduction to Physics II Laboratory	1

Upper-Division Courses

Statistics

Two statistics courses:

STAT 131	Introduction to Probability Theory	5
	AND
	Either one of these courses
STAT 132	Classical and Bayesian Inference	5
STAT 206	Applied Bayesian Statistics	5

Biochemistry and Molecular Biology

All of the following courses:

BIOC 100A	Biochemistry and Molecular Biology	5
BIOC 100B	Biochemistry and Molecular Biology	5

Biomolecular Engineering

Choose one of the following courses:

BME 105	Genetics in the Genomics Era	5
BIOL 105	Genetics	5

BME 105 is strongly recommended.

Plus all of the following courses:

BME 110	Computational Biology Tools	5
BME 160	Research Programming in the Life Sciences	6
BME 163	Applied Visualization and Analysis of Scientific Data	3

Plus one of the following Modeling/Design sequences:

	Either these courses
BME 128	Protein Engineering	5
BME 128L	Protein Engineering Laboratory	2
	or these courses
BME 177	Engineering Stem Cells	5
BME 177L	Engineering Stem Cell Laboratory	2
	or this course
AM 115	Stochastic Modeling in Biology	5

Technical Writing (one of the following courses)

BME 185	Technical Writing for Biomolecular Engineers	5
CSE 185E /CSE 185S	Technical Writing for Computer Science and Engineering	5

BME 185 is recommended, as CSE 185E has additional prerequisites.

Elective

One of the following (the course taken to satisfy this elective cannot be used to satisfy other requirements of the major):

AM 147	Computational Methods and Applications	5
METX 100	Introduction to Microbiology	5
METX 140	Molecular Biology and Microbial Genetics	5
BIOC 100C	Biochemistry and Molecular Biology	5
BIOL 115	Eukaryotic Molecular Biology	5
BME 118	Mathematics of the Mind	5
BME 122H	Extreme Environmental Virology	5
BME 128	Protein Engineering	5
BME 128L	Protein Engineering Laboratory	2
BME 130	Genomes	5
BME 132	Evolutionary Genomics	5
BME 140	Bioinstrumentation	5
BME 175	Entrepreneurship in Biotechnology	5
BME 177	Engineering Stem Cells	5
BME 177L	Engineering Stem Cell Laboratory	2
BME 178	Stem Cell Biology	5
ECE 104	Bioelectronics	5
	or any 5-credit biomolecular engineering graduate course

Disciplinary Communication (DC) Requirement

Students of every major must satisfy that major's upper-division Disciplinary Communication (DC) requirement. Biomolecular engineering and bioinformatics majors satisfy the DC requirement by completing one of the following courses:

BME 185	Technical Writing for Biomolecular Engineers	5
CSE 185E /CSE 185S	Technical Writing for Computer Science and Engineering	5

BME 185 is recommended, as CSE 185E has additional prerequisites.

Comprehensive Requirement

All biomolecular engineering concentration students must complete a senior capstone project as a group project, as a series of Advanced Bioinformatics courses, or as an individual senior thesis doing research in a faculty laboratory.

Note that the Technical Writing requirement is a prerequisite for all the capstone options, including the senior thesis. Students pursuing the senior thesis option must write a two-page thesis proposal and seek approval of their project from the undergraduate director in the quarter preceding the independent study courses, typically spring quarter of the third year. Students are responsible for ensuring that they meet the prerequisites for whichever capstone they choose.

To complete the senior capstone requirement, Biomolecular Engineering concentrations students must complete one of the following:

	Either these courses
BME 129A	Project Design and Implementation in Biomolecular Engineering I	5
BME 129B	Project Design and Implementation in Biomolecular Engineering II	5
BME 129C	Project Design and Implementation in Biomolecular Engineering III	5
	or these courses
BME 180	Professional Practice in Bioengineering	2
BME 188A	Synthetic Biology--Mentored Research A	2
BME 188B	Synthetic Biology--Mentored Research B	5
BME 188C	Synthetic Biology Mentored Research C	5
	or these courses
BME 205	Bioinformatics Models and Algorithms	5
BME 230A	Introduction to Computational Genomics and Systems Biology	5
	or these courses
BME 193	Field Study	5
BME 123T	Senior Thesis Writing	5
	or these courses
BME 195	Senior Thesis Research	5
BME 123T	Senior Thesis Writing	5
	or these courses
BME 198	Individual Study or Research	5
BME 123T	Senior Thesis Writing	5

The thesis option consists of 12 credits of Independent Study (BME 198). Field Study (BME 193), or Senior Thesis Research (BME 195) in biomolecular engineering; and BME 123T, Senior Thesis Presentation, 5 credits.

Students pursuing the senior thesis option must write a two-page thesis proposal and seek approval of their project from the undergraduate director in the quarter preceding the independent study courses, typically spring quarter of the third year.

Students spend three or more quarters working on their thesis projects. Thesis students must enroll in BME 123T, Senior Thesis Presentation, before completing their thesis.

Exit Requirements

Students are required to submit a portfolio, exit survey, and attend an exit interview.

The portfolios must be turned in electronically as PDF files by the last day of the quarter of graduation, and will be reviewed quarterly by the undergraduate director.

Portfolios must contain the following:

A substantial written report on a modeling/design project. This is typically satisfied by a senior thesis, or a written capstone project report.
Slides from a substantial verbal presentation. This is typically satisfied by a capstone design presentation, Stem Cell Engineering, or other design courses.
A research poster. This is typically satisfied by a senior thesis poster or a capstone design project poster, presented at the undergraduate poster symposium.

The three parts of the portfolio should represent at least two different design projects. If a senior thesis is completed, it must be provided as the written report. If a capstone project is completed, it must be provided as one (or more) of the three submissions.

Exit interviews are scheduled during the last week of the quarter by Baskin Engineering advising office, generally as small group interviews.

Planners

The tables below are for informational purposes and do not reflect all university, general education, and credit requirements. See Undergraduate Graduation Requirements for more information.

Every biomolecular engineering and bioinformatics major must have a faculty advisor, assigned by Baskin Engineering's undergraduate advising office, and with that advisor must formulate a program of proposed coursework that meets the major requirements. The choice of capstone and electives should be made early, so that the plan can be tailored to fit in the chosen courses.

As in all engineering and science programs, it is recommended that students spread their general education requirements out over all 12 quarters. Delaying a general education requirement is safer than delaying a major requirement.

It is recommended that students reserve the summer after the junior year for undergraduate research.

Curriculum charts for the major are available on the BSOE website.

Sample Plan: Biomolecular Engineering Concentration

Year	Fall	Winter	Spring	Summer
Entering				College 1A
				Summer Edge (optional)

1st (frosh)	CHEM 3A	MATH 19B	AM 10
	MATH 19A	CHEM 3B & CHEM 3BL	CHEM 3C & CHEM 3CL
		WRIT 1/WRIT 1E (if needed)	BME 21L
2nd (soph)	BME 22L	BME 23L	BME 105
	CHEM 8A	CHEM 8B	PHYS 5B & PHYS 5M
	BIOL 20A	PHYS 5A & PHYS 5L
	WRIT 2*	AM 20
3rd (junior)	BIOC 100A	BIOC 100B	AM 115
	BME 110	BME 160	BME 163
	BME 185	STAT 131
4th (senior)	BME 129A	BME 129B	BME 129C
4th (senior)	BME 80G	STAT 132	Elective

* WRIT 2 should be taken in or before spring quarter of the second year.

Students who can take Organic Chemistry (CHEM 8A and CHEM 8B, or transferable equivalents) in summer after their first year can take BIOC 100A in their second year and be ready to join a research lab a year earlier. Here is an alternative plan for students who do organic chemistry in summer.

Sample Plan: Biomolecular Engineering Concentration (CHEM 8A & CHEM 8B In summer after first year)

Year	Fall	Winter	Spring	Summer
Entering				College 1A
				Summer Edge (optional)

1st (frosh)	CHEM 3A	MATH 19B	BIOL 20A
	MATH 19A	CHEM 3B & CHEM 3BL	CHEM 3C & CHEM 3CL
		WRIT 1/WRIT 1E (if needed)	BME 21L
2nd (soph)	BME 22L	BME 23L	BME 105
	BIOC 100A	BIOC 100B	PHYS 5B & PHYS 5M
	BME 80G	PHYS 5A & PHYS 5L
	WRIT 2*
3rd (junior)	BME 185	AM 20
	BME 110	BME 160	BME 163
	AM 10
4th (senior)	BME 129A	BME 129B	BME 129C
	STAT 131	STAT 132	Elective
			AM 115

* WRIT 2 should be taken in or before spring quarter of the second year.

General education requirements:

CC, ER, and IM are not met by any courses in the program.

MF, SI, SR and PE are met by required courses.

TA can be met by several electives: BME 122H, BME 132, BME 177, or BME 178.

PR-E can be met by some capstone options: BME 129C or BME 180.

C is not met by courses in the program, but is a prerequisite for the required BME 185 or CSE 185E course.

Transfer planner

Year	Fall	Winter	Spring	Summer
Entering				KRSG 1T
				Summer Edge (optional)

1st (junior)	BIOC 100A	BIOC 100B	BME 105
	BME 80G	BME 110	BME 160
	BME 185	AM 20	PHYS 5B & PHYS 5M
	BME 22L	BME 23L
2nd(senior)	BME 129A	BME 129B	BME 129C
	STAT 131	STAT 132	BME 163
	Elective		AM 115

This transfer planner assumes that a student has completed the equivalent of CHEM 1A, CHEM 1B, CHEM 1M, CHEM 1C, CHEM 1N, CHEM 8A, CHEM 8B, MATH 19A, MATH 19B, PHYS 5A, PHYS 5L, BIOL 20A, AM 10, a molecular biology lab, and all general education courses before coming to UC Santa Cruz. Students are also expected to have completed all the general education requirements, except those covered by the required courses. This planner is only a proof-of-concept that the major can be completed in another two years; each student will need to work with an advisor to tailor their own schedule.

Bioinformatics Concentration

The bioinformatics concentration focuses on dry-lab (computational) techniques.

Bioinformatics concentration majors must complete the following courses:

Course Requirements

Lower-Division Courses

Biology

BIOL 20A

Cell and Molecular Biology

Biomolecular Engineering

BME 80G

/PHIL 80G

Bioethics in the 21st Century: Science, Business, and Society

Chemistry

All of the following courses:

	Either these courses
CHEM 1A	General Chemistry	5
CHEM 1B	General Chemistry	5
CHEM 1M	General Chemistry Laboratory	2
CHEM 1C	General Chemistry	5
CHEM 1N	General Chemistry Laboratory	2
	or these courses
CHEM 3A	General Chemistry	5
CHEM 3B	General Chemistry	3
CHEM 3C	General Chemistry	3
CHEM 3BL	General Chemistry Lab	2
CHEM 3CL	General Chemistry Lab	2
	or these courses
CHEM 4A	Advanced General Chemistry: Molecular Structure and Reactivity	5
CHEM 4B	Advanced General Chemistry: Molecular Structure and Reactivity	5
CHEM 4BL	Advanced General Chemistry Lab	2
CHEM 4AL	Advanced General Chemistry Lab	2

Organic Chemistry

all of the following courses:

CHEM 8A	Organic Chemistry	5
CHEM 8B	Organic Chemistry	5

Computer Science and Engineering

All the following courses:

CSE 13S	Computer Systems and C Programming	7
CSE 16	Applied Discrete Mathematics	5
CSE 30	Programming Abstractions: Python	7
CSE 101	Introduction to Data Structures and Algorithms	5

BME 160 is prerequisite to both CSE 13S and CSE 30.

Mathematics

Choose one of the following options:

	Either these courses
MATH 19A	Calculus for Science, Engineering, and Mathematics	5
MATH 19B	Calculus for Science, Engineering, and Mathematics	5
AM 10	Mathematical Methods for Engineers I	5
	or these courses
MATH 20A	Honors Calculus	5
MATH 20B	Honors Calculus	5
AM 10	Mathematical Methods for Engineers I	5

Students may substitute MATH 21 for AM 10, if they can show MATLAB proficiency at the level of students in the AM class.

Upper-Division Courses

Statistics

Two statistics courses:

STAT 131	Introduction to Probability Theory	5
	AND
	Either one of these courses
STAT 132	Classical and Bayesian Inference	5
STAT 206	Applied Bayesian Statistics	5

Biochemistry and Molecular Biology

BIOC 100A

Biochemistry and Molecular Biology

Biomolecular Engineering

Plus one of the following courses:

BME 105	Genetics in the Genomics Era	5
BIOL 105	Genetics	5

BME 105 is strongly recommended.

Plus all of the following courses:

BME 110	Computational Biology Tools	5
BME 160	Research Programming in the Life Sciences	6
BME 163	Applied Visualization and Analysis of Scientific Data	3

Plus one of the following Modeling/Design sequences:

	Either these courses
AM 20	Mathematical Methods for Engineers II	5
AM 115	Stochastic Modeling in Biology	5
	or these courses
AM 30	Multivariate Calculus for Engineers	5
CSE 142	Machine Learning	5
	or these courses
AM 30	Multivariate Calculus for Engineers	5
CSE 144	Applied Machine Learning: Deep Learning	5

Students may substitute MATH 24 for AM 20, and MATH 22 or MATH 23A for AM 30 , if they can show MATLAB proficiency at the level of students in the AM class that they are replacing.

Technical Writing

Choose one of the following courses:

BME 185	Technical Writing for Biomolecular Engineers	5
CSE 185E /CSE 185S	Technical Writing for Computer Science and Engineering	5

CSE 185E is recommended, as it has more focus on writing about computer programming and includes some LaTeX instruction.

Elective

One of the following (courses satisfying an elective cannot be used to satisfy other requirements of the major):

AM 147	Computational Methods and Applications	5
BME 118	Mathematics of the Mind	5
BME 122H	Extreme Environmental Virology	5
BME 128	Protein Engineering	5
BME 128L	Protein Engineering Laboratory	2
BME 130	Genomes	5
BME 132	Evolutionary Genomics	5
BME 140	Bioinstrumentation	5
BME 175	Entrepreneurship in Biotechnology	5
BME 177	Engineering Stem Cells	5
BME 177L	Engineering Stem Cell Laboratory	2
BME 178	Stem Cell Biology	5
BIOC 100B	Biochemistry and Molecular Biology	5
CSE 142	Machine Learning	5
CSE 144	Applied Machine Learning: Deep Learning	5
METX 100	Introduction to Microbiology	5
METX 140	Molecular Biology and Microbial Genetics	5
	or any 5-credit biomolecular engineering graduate course

Database management

The following course is required:

CSE 182

Introduction to Database Management Systems

CSE 180 may be substituted for CSE 182, but BMEB students do not have registration priority.

Disciplinary Communication (DC) Requirement

BME 185	Technical Writing for Biomolecular Engineers	5
CSE 185E /CSE 185S	Technical Writing for Computer Science and Engineering	5

Comprehensive Requirement

The senior capstone is fulfilled by completing all of the following courses:

BME 205	Bioinformatics Models and Algorithms	5
BME 230A	Introduction to Computational Genomics and Systems Biology	5

Exit Requirements

Students are required to submit a portfolio, exit survey, and attend an exit interview.

The portfolios must be turned in electronically as PDF files by the last day of the quarter of graduation, and will be reviewed quarterly by the undergraduate director.

Portfolios must contain the following:

A substantial written report on a modeling/design project. This is typically satisfied by a senior thesis, or a written capstone project report.
Slides from a substantial verbal presentation. This is typically satisfied by a capstone design presentation, Stem Cell Engineering, or other design courses.
A research poster. This is typically satisfied by a senior thesis poster or a capstone design project poster, presented at the undergraduate poster symposium.

Exit interviews are scheduled during the last week of the quarter by the Baskin Engineering advising office, generally as small group interviews.

Planners

The tables below are for informational purposes and do not reflect all university, general education, and credit requirements. See Undergraduate Graduation Requirements for more information.

Every biomolecular engineering and bioinformatics major must have a faculty advisor, assigned by the Baskin Engineering undergraduate advising office, and with that advisor must formulate a program of proposed coursework that meets the major requirements. The choice of capstone and electives should be made early, so that the plan can be tailored to fit in the chosen courses.

It is recommended that students reserve the summer after the junior year for undergraduate research.

Curriculum charts for the major are available on the BSOE website.

Sample Plan: Bioinformatics Concentration

Year	Fall	Winter	Spring	Summer
Entering				College 1A
				Summer Edge (optional)

1st (frosh)	CHEM 3A	CHEM 3B & CHEM 3BL	CHEM 3C & CHEM 3CL
	MATH 19A	MATH 19B	BIOL 20A
	College 1	WRIT 1/WRIT 1E (if needed)
2nd (soph)	CHEM 8A	CHEM 8B	BME 105
	AM 10	CSE 16	BME 160
	BME 80G		AM 30
	WRIT 2*
3rd (junior)	BIOC 100A	CSE 13S	BME 163
	STAT 131	STAT 132	CSE 101
	CSE 30		CSE 182
4th (senior)	BME 205	BME 230A	Elective
	BME 110	CSE 185E	CSE 144

* WRIT 2 should be taken in or before spring quarter of the second year.

General education requirements:

CC, ER, IM, and PR-E are not met by any courses in the program.

MF, PE-T, SI, and SR are met by required courses.

TA can be met by several electives: BME 122H, BME 132, BME 177, or BME 178.

C is not met by courses in the program, but is a prerequisite for the required BME 185 or CSE 185E course.

Transfer planner

Year	Fall	Winter	Spring	Summer
Entering				KRSG 1T
				Summer Edge (optional)

3rd (junior)	BIOC 100A	BME 110	BME 105
	AM 10	BME 160	BME 163
	STAT 131	STAT 132	CSE 30
4th (senior)	BME 205	BME 230A	Elective
	BME 80G	CSE 185E	CSE 182
	CSE 101	CSE 144	AM 30

This transfer planner assumes that a student has completed the equivalent of CHEM 1A, CHEM 1B, CHEM 1M, CHEM 1C, CHEM 1N, CHEM 8A, CHEM 8B, MATH 19A, MATH 19B, BIOL 20A, CSE 16, and CSE 13S and all general education requirements, except those covered by the required courses. This planner is only a proof-of-concept that the major can be completed in another two years; each student will need to work with an advisor to tailor their own schedule.